Margo C E, Trobe J D, Shuster J J
Acta Ophthalmol (Copenh). 1982 Aug;60(4):533-46. doi: 10.1111/j.1755-3768.1982.tb00598.x.
A critical review of published ophthalmic histocompatibility antigen association studies found numerous conflicting or ambiguous reports. Methodologic errors that could account for these discrepancies were categorized into 3 groups (1) arbitrary application of statistical methods to determine significance, (2) poor sampling design, and (3) variable disease definition. Multivariate analysis, not previously applied in this area provides a more powerful tool for assessing statistical significance. A computer program using this methodology for large studies is now available.
一项对已发表的眼科组织相容性抗原关联研究的批判性综述发现了大量相互矛盾或含糊不清的报告。可能导致这些差异的方法学错误被分为3组：（1）任意应用统计方法来确定显著性，（2）抽样设计不佳，以及（3）疾病定义多变。多变量分析，此前未应用于该领域，为评估统计显著性提供了一个更强大的工具。现在有一个使用这种方法进行大型研究的计算机程序。
