Danks D M, Campbell P E, Smith A L, Rogers J
Arch Dis Child. 1977 May;52(5):368-72. doi: 10.1136/adc.52.5.368.
105 babies with neonatal hepatitis were studied carefully and followed for up to 11 1/2 years. Ascertainment was complete for those with severe and persistent jaundice, but less complete for mild or anicteric cases. Prognosis was found to be poor (40% death or cirrhosis) in babies with perisitently acholic stools, but relatively good (less than 15% death or cirrhosis) in those with jaundice which was less persistent and less obstructive. The presence of second diseases (including alpha1-antitrypsin deficiency or a family history of other affected children) seemed to play a part in determining poor prognosis. A distinctive group of babies (22 cases) presented with acute fulminant illness (with or without jaundice) in the neonatal period. Cytomegalovirus infection carried a relatively good prognosis. Guidelines for selection of patients for therapeutic trials are suggested.
对105例新生儿肝炎患儿进行了仔细研究，并随访了长达11年半的时间。对于重度和持续性黄疸患儿，诊断是完整的，但对于轻度或无黄疸病例，诊断则不那么完整。发现持续性无胆汁粪便的患儿预后较差（40%死亡或肝硬化），而黄疸持续时间较短且梗阻性较小的患儿预后相对较好（死亡或肝硬化的比例低于15%）。第二种疾病（包括α1-抗胰蛋白酶缺乏症或其他患病儿童的家族史）的存在似乎在决定预后不良方面起了一定作用。有一组特殊的患儿（22例）在新生儿期出现急性暴发性疾病（有或无黄疸）。巨细胞病毒感染的预后相对较好。文中还提出了治疗试验患者选择的指导原则。
