Hentzer B, Kobayasi T
Ann Trop Med Parasitol. 1977 Jun;71(2):157-66. doi: 10.1080/00034983.1977.11687174.
The effect of the antiprotozoal drug pentamidine on the ultrastructure of the amastigote stage of Leishmania tropica was studied. The most remarkable change introduced by the treatment occurred in the kinetoplast-mitochondrion complex. All mitochondria were extremely enlarged and most kinetoplasts disintegrated into a network of fine filaments. The flagellar pocket was frequently dilated and filled with various quantities of double-membrane bounded bodies ejected from the pocket wall. The multivesicular bodies and lipid droplets were enlarged. The number of ribosomal granules decreased. Many protozoa had an irregular shape and damaged internal structure. The drug-induced changes of L. tropica are discussed in relation to similar effects previously observed in trypanosomes.
研究了抗寄生虫药物喷他脒对热带利什曼原虫无鞭毛体阶段超微结构的影响。治疗引起的最显著变化发生在动基体-线粒体复合体。所有线粒体都极度增大，大多数动基体解体成细丝网络。鞭毛袋经常扩张，充满从袋壁喷出的各种数量的双膜包被小体。多囊泡体和脂滴增大。核糖体颗粒数量减少。许多原生动物形状不规则，内部结构受损。结合先前在锥虫中观察到的类似效应，讨论了喷他脒对热带利什曼原虫的诱导变化。
