Heydorn W H, Zajtchuk R, Miller J, Schuchmann G F
Ann Thorac Surg. 1977 Jun;23(6):539-44. doi: 10.1016/s0003-4975(10)63698-3.
In an effort to evaluate polytetrafluoroethylene (Gore-Tex) as a replacement for large veins, tubular grafts of the material were substituted for the precava in 33 mongrel dogs weighing 15 to 30 kg. Thirteen dogs had grafts 10 cm long by 12 mm wide with a 15-to 30 micron pore size; 15 dogs had grafts of the same length and width from 90-micron pore size material; and 5 dogs had grafts 5 cm long by 12 mm wide, of 90-micron pore size Gore-Tex. The effect of Gore-Tex tubes with and without spiral support and the differences in anatomical positions of the grafts were evaluated in terms of patency. Dogs were killed if a venogram showed occlusion of the graft. Twelve dogs survived 90 days; the longest survivor was killed at eleven months. At postmortem examination, the graft was patent but extremely narrow at the atrial end. Modification in the fabrication of Gore-Tex may eliminate factors contributing to graft failure; experiments longer than 90 days are necessary to evaluate Gore-Tex as a large vein replacement material. The 90-micron pore size material used in this experiment was unsuitable as a canine venous substitute.
为了评估聚四氟乙烯（戈尔特斯）作为大静脉替代物的效果，在33只体重15至30千克的杂种犬中，用该材料制成的管状移植物替代了前腔静脉。13只犬植入了长10厘米、宽12毫米、孔径为15至30微米的移植物；15只犬植入了相同长度和宽度、由孔径90微米材料制成的移植物；5只犬植入了长5厘米、宽12毫米、孔径90微米的戈尔特斯移植物。从通畅情况方面评估了有无螺旋支撑的戈尔特斯管以及移植物在解剖位置上的差异。如果静脉造影显示移植物闭塞，则将犬处死。12只犬存活了90天；存活时间最长的在11个月时被处死。尸检时，移植物通畅，但在心房端极其狭窄。戈尔特斯制作工艺的改进可能会消除导致移植物失败的因素；需要进行超过90天的实验来评估戈尔特斯作为大静脉替代材料的效果。本实验中使用的孔径90微米的材料不适合作犬类静脉替代物。
