Heydorn W H, Geasling J W, Moores W Y, Lollini L O, Gomez A C
Ann Thorac Surg. 1979 Feb;27(2):173-7. doi: 10.1016/s0003-4975(10)63263-8.
Polytetrafluoroethylene (PTFE) has been used clinically and experimentally as a vein substitute. Since its introduction, changes have been made in the manufacture of the material. This study was designed to evaluate the effects of pore size (fibril length), PTFE cover, and spiral tube support on long-term patency and histological behavior when this material is used as a replacement for the precava in the dog. A graft of 30-mu pore size has adequate fibroblastic ingrowth, a neointima of 200 mu or less, and the best long-term patency. The PTFE cover results in less fibroblastic involvement of the prosthetic graft and prevents late occlusion caused by transmural fibrosis in the 90-mu graft. The spiral support does not affect patency and may be indicated when external pressure on the tube must be avoided.
聚四氟乙烯（PTFE）已在临床和实验中用作静脉替代物。自其引入以来，该材料的制造工艺已有所改进。本研究旨在评估当该材料用作犬类前腔静脉替代物时，孔径（原纤维长度）、PTFE 覆盖层和螺旋管支撑对长期通畅性和组织学行为的影响。孔径为 30 微米的移植物有足够的成纤维细胞向内生长，新生内膜厚度为 200 微米或更小，且长期通畅性最佳。PTFE 覆盖层可减少人工血管的成纤维细胞浸润，并防止 90 微米移植物因透壁纤维化导致的晚期闭塞。螺旋支撑不影响通畅性，当必须避免对管子施加外部压力时可能适用。
