Hori T, Katafuchi T, Take S, Kaizuka Y, Ichijo T, Shimizu N
Department of Physiology, Kyushu University Faculty of Medicine, Fukuoka, Japan.
Neurobiology (Bp). 1995;3(3-4):309-17.
Our findings reviewed in this article have revealed that the stimulation of opioid receptors of the hypothalamic neurons by interferon alpha and beta-endorphin synthesized in the brain or by stress causing the opioid-dependent analgesia suppresses the natural killer cytotoxicity, an important component of immunosurveillance, through an activation of the hypothalamic CRF-sympathetic nervous system.
本文所综述的我们的研究结果显示，大脑中合成的α干扰素和β内啡肽对下丘脑神经元阿片受体的刺激，或导致阿片依赖型镇痛的应激，通过激活下丘脑促肾上腺皮质激素释放因子-交感神经系统，抑制了免疫监视的一个重要组成部分——自然杀伤细胞的细胞毒性。
