用于含氮酸性和中性药物气相色谱定性的四种同源保留指数标准系列的比较。

Comparison of four homologous retention index standard series for qualitative gas chromatography of nitrogenous acidic and neutral drugs.

作者信息

Rasanen I, Ojanperä I, Vuori E, Hase T A

机构信息

Department of Forensic Medicine, University of Helsinki, Finland.

出版信息

J Chromatogr A. 1996 Jul 12;738(2):233-9. doi: 10.1016/0021-9673(96)00095-7.

DOI:10.1016/0021-9673(96)00095-7

PMID:8696505

Abstract

Four homologous retention index standard series, the alkylmethylhydantoins, alkylhydantoins, alkylmaleimides and alkylbis(trifluoromethyl)phosphine sulphides, were evaluated for the screening of blood samples for acidic and neutral drugs on Ultra 2 and HP-1701 capillary columns over a six-month period. An index series consisting of actual drug substances was used as a standard of comparison. All the series produced high precision, and the precision differences between the series were rather small. Considering the limitations of the other series, the alkylmethylhydantoins and alkylhydantoins turned out to be the most feasible internal retention index standard series in the present dual column setting.

摘要

在六个月的时间里，对四个同源保留指数标准系列，即烷基甲基乙内酰脲、烷基乙内酰脲、烷基马来酰亚胺和烷基双（三氟甲基）硫化膦，在Ultra 2和HP - 1701毛细管柱上进行了评估，用于筛查血液样本中的酸性和中性药物。由实际药物物质组成的指数系列用作比较标准。所有系列都具有很高的精密度，系列之间的精密度差异相当小。考虑到其他系列的局限性，在目前的双柱设置中，烷基甲基乙内酰脲和烷基乙内酰脲被证明是最可行的内部保留指数标准系列。