抗肿瘤化合物的研究。十二。生物学研究。12种新型1-硝基-9-烷基氨基烷基氨基吖啶的抗肿瘤特性

A search for antitumor compounds. XII. Biologic studies. Antitumor properties of 12 new 1-nitro-9alkylaminoalkylaminoacridines.

作者信息

Hrabowska M, Ledóchowski A, Onoszko K

出版信息

Arch Immunol Ther Exp (Warsz). 1977;25(2):253-62.

Abstract

Results of the studies on antitumor activity of 12 new 1-nitro-9-alkylaminoalkylaminacridines in mice bearing Sa-180 are presented. Only one of these compounds, viz. C-846 was active repeatedly in Sa-180 test; the activity of 5 other compounds tested (C-845, C-848, C-852, C-865 and C-866) requires further elucidation by means of new tests with Sa-180. The remaining 6 compounds were inactive. Some other general effects in mice bearing Sa-180 and some aspects of the structure-activity relationship are discussed.

摘要

本文介绍了12种新型1-硝基-9-烷基氨基烷基氨基吖啶对荷Sa-180小鼠的抗肿瘤活性研究结果。这些化合物中只有一种，即C-846在Sa-180试验中反复表现出活性；其他5种受试化合物（C-845、C-848、C-852、C-865和C-866）的活性需要通过对Sa-180进行新的试验进一步阐明。其余6种化合物无活性。文中还讨论了对荷Sa-180小鼠的一些其他一般影响以及构效关系的某些方面。

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