Hrabowska M, Ledóchowski A, Wysocka-Skrzela B, Onoszko K, Paradziej-Lukowicz J
Arch Immunol Ther Exp (Warsz). 1981;29(2):205-16.
Results of the studies on antitumor activity of 20 acridines and related compounds (19 of them were new) in Sa-180-bearing mice are presented. Only several of these compounds i.e. C-258, C-829, C-874, and C-899(21) appeared to inhibit the Sa-180 growth; the activity of the two other compounds (C-783(21) and C-755(21)) requires confirmation in further experiments. The remaining 14 compounds were inactive. Some other general effects exerted by the compounds tested in Sa-180-bearing mice and some aspects of the structure-activity relationship are discussed.
本文给出了对20种吖啶及其相关化合物（其中19种为新化合物）在接种Sa - 180肿瘤的小鼠体内抗肿瘤活性的研究结果。这些化合物中只有几种，即C - 258、C - 829、C - 874和C - 899(21)，似乎能抑制Sa - 180肿瘤的生长；另外两种化合物（C - 783(21)和C - 755(21)）的活性需要在进一步实验中得到证实。其余14种化合物无活性。文中还讨论了在接种Sa - 180肿瘤的小鼠体内测试的这些化合物产生的其他一些一般效应以及构效关系的一些方面。
