Morris R W, McCallum A K, Walker M, Whincup P H, Ebrahim S, Shaper A G
Department of Primary Care and Population Sciences, Royal Free Hospital School of Medicine, London.
Heart. 1996 Jun;75(6):557-62. doi: 10.1136/hrt.75.6.557.
To examine the relation between smoking status, clinical need, and likelihood of coronary artery bypass grafting in middle aged men.
A prospective study of cardiovascular disease in British men aged 40 to 59 years, screened in 1978-80 and followed until December 1991.
7735 men drawn from one general practice in each of 24 British towns.
Coronary artery bypass graft surgery.
Of the 3185 current smokers, 38 (1.03/1000/year) underwent coronary artery bypass surgery compared with 47 of 2715 (1.45/1000/year) ex-smokers, and 19 of 1817 (0.85/1000/year) never-smokers. Ex-smokers had a lower incidence of major ischaemic heart disease during follow up than current smokers. After adjustment for incidence of ischaemic heart disease during follow up, the hazard ratio of coronary artery bypass surgery for ex-smokers compared with smokers was 1.52 (95% confidence interval 0.99 to 2.34). Ex-smokers were more likely at screening to recall a doctor diagnosis of ischaemic heart disease than smokers (7.1% v 5.3%), but among those who recalled a doctor diagnosis, smokers were less likely to undergo coronary artery bypass surgery than ex-smokers (9.4% v 3.5%, P = 0.026). By 1992, men defined as smokers at screening were no less likely than ex-smokers to have been referred to a cardiologist (18.5% v 18.8%), nor to report having undergone coronary angiography less frequently than ex-smokers (12.7% v 11.4%).
Even allowing for the strong relation between coronary artery bypass surgery and clinical need, continuing smokers were less likely to undergo coronary artery bypass surgery than ex-smokers. A complex interplay exists between the men's experience of heart disease, the decision to stop smoking, and the willingness of doctors to consider coronary artery bypass surgery.
研究中年男性的吸烟状况、临床需求与冠状动脉搭桥术可能性之间的关系。
对1978 - 1980年筛查的40至59岁英国男性心血管疾病进行前瞻性研究,随访至1991年12月。
从英国24个城镇的每个一个普通诊所选取7735名男性。
冠状动脉搭桥手术。
在3185名当前吸烟者中,38人(1.03/1000/年)接受了冠状动脉搭桥手术;相比之下,2715名既往吸烟者中有47人(1.45/1000/年),1817名从不吸烟者中有19人(0.85/1000/年)接受了该手术。既往吸烟者在随访期间主要缺血性心脏病的发病率低于当前吸烟者。在对随访期间缺血性心脏病发病率进行调整后,既往吸烟者与吸烟者相比,冠状动脉搭桥手术的风险比为1.52(95%置信区间0.99至2.34)。既往吸烟者在筛查时比吸烟者更有可能回忆起医生诊断的缺血性心脏病(7.1%对5.3%),但在那些回忆起医生诊断的人中,吸烟者接受冠状动脉搭桥手术的可能性低于既往吸烟者(9.4%对3.5%,P = 0.026)。到1992年,筛查时被定义为吸烟者被转诊至心脏病专家的可能性与既往吸烟者无异(18.5%对18.8%),报告接受冠状动脉造影的频率也不比既往吸烟者低(12.7%对11.4%)。
即使考虑到冠状动脉搭桥手术与临床需求之间的密切关系,持续吸烟者接受冠状动脉搭桥手术的可能性仍低于既往吸烟者。男性的心脏病经历、戒烟决定以及医生考虑冠状动脉搭桥手术的意愿之间存在复杂的相互作用。