Joshi R R, Krishnanand K
Department of Mathematics, Indian Institute of Technology, Powai, Bombay, India.
J Comput Biol. 1996 Spring;3(1):143-62. doi: 10.1089/cmb.1996.3.143.
Adaptive learning properties (of clonal selection and affinity maturation) in the immune network model are investigated in this paper under a nonlinear data structural representation of the involved molecules. Weighted trees are constructed to model the multiple paratopes/epitopes on the antibodies/antigens. Parallel computing experiments are carried out for the canonical coding of these trees and the corresponding multiple matching interactions. Our experiments on real data have shown significant results on the cognitive properties of the immune network. These and other computational results are presented along with a discussion of future applications.
本文在相关分子的非线性数据结构表示下,研究了免疫网络模型中(克隆选择和亲和力成熟的)适应性学习特性。构建加权树以模拟抗体/抗原上的多个互补决定区/表位。针对这些树的规范编码以及相应的多重匹配相互作用进行了并行计算实验。我们对真实数据的实验在免疫网络的认知特性方面取得了显著成果。展示了这些以及其他计算结果,并讨论了未来的应用。