Kwon D J, Kim J H, Chung K W, Kim J H, Lee J W, Kim S P, Lee H Y
Department of Obstetrics and Gynecology, Catholic University Medical College, Uijeongbu Saint Mary's Hospital, Gyeonggi-do, Korea.
J Obstet Gynaecol Res. 1996 Apr;22(2):157-62. doi: 10.1111/j.1447-0756.1996.tb00959.x.
To evaluate the influence of non-insulin-dependent diabetes mellitus (NIDDM) on bone mineral density (BMD), we measured BMD in 185 female patients with NIDDM using dual energy X-ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2-4). BMD is slightly higher in the diabetic patients compared with control subjects and bone loss related to menopause starts before the onset of menopause. The BMD of postmenopausal women showed a definite decrease with aging and there was abrupt bone loss after 55 years of age (p < 0.05). In relation to the duration of diabetes, the decrease of BMD for 15 years was 10.0%. BMD was negatively correlated with age, years since menopause (YSM), and disease duration (r = -0.584, r = -0.470, r = -0.186). These results suggest that age, YSM, and the duration of disease appear to be the risk factors for decreased BMD in the diabetic patients.
为评估非胰岛素依赖型糖尿病（NIDDM）对骨密度（BMD）的影响，我们使用双能X线吸收法（DEXA）测量了185例NIDDM女性患者的骨密度。在腰椎（L2 - 4）测量骨密度。糖尿病患者的骨密度略高于对照组，且与绝经相关的骨质流失在绝经前就已开始。绝经后女性的骨密度随年龄增长呈明显下降，55岁后出现骨质突然流失（p < 0.05）。与糖尿病病程相关，15年的骨密度下降为10.0%。骨密度与年龄、绝经年限（YSM）和病程呈负相关（r = -0.584，r = -0.470，r = -0.186）。这些结果表明，年龄、YSM和病程似乎是糖尿病患者骨密度降低的危险因素。
