Wakasugi M, Wakao R, Tawata M, Gan N, Koizumi K, Onaya T
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Bone. 1993;14(1):29-33. doi: 10.1016/8756-3282(93)90252-6.
Because of the previous controversial findings in diabetic patients with older methodologies, we assessed bone mineral density (BMD) in 78 patients (38 males and 40 females) with non-insulin-dependent diabetes mellitus using dual energy x-ray absorptiometry (DEXA). BMD was measured in lumbar vertebrae (L2-4). The BMD of each patient was calculated as the percentage of the mean value (%BMD) obtained from a healthy control group matched for sex and age. The %BMD of the patients with diabetes was about 100% for females and 96% for males, as compared with BMD of normal controls. The %BMD of the patients with diabetes was significantly correlated with body mass index and urinary C peptide level, and inversely correlated with age and duration of diabetes within 20 years. No relationships were found between %BMD and serum calcium, phosphorus, or glycosylated hemoglobin A1C levels. These observations suggest that metabolic abnormalities associated with diabetes mellitus alter the BMD, and that such factors as duration of the disease and deficit in insulin secretion are risk factors for decreased BMD.
由于既往采用较陈旧方法对糖尿病患者进行研究时结果存在争议，我们使用双能X线吸收法（DEXA）对78例非胰岛素依赖型糖尿病患者（38例男性和40例女性）的骨密度（BMD）进行了评估。在腰椎（L2 - 4）测量骨密度。将每位患者的骨密度计算为来自性别和年龄匹配的健康对照组的平均值的百分比（%BMD）。与正常对照组的骨密度相比，糖尿病女性患者的%BMD约为100%，男性患者为96%。糖尿病患者的%BMD与体重指数和尿C肽水平显著相关，与年龄及20年内的糖尿病病程呈负相关。未发现%BMD与血清钙、磷或糖化血红蛋白A1C水平之间存在关联。这些观察结果表明，与糖尿病相关的代谢异常会改变骨密度，并且病程和胰岛素分泌不足等因素是骨密度降低的危险因素。
