Wallow I H, Tso M O, Elgin S
Arch Ophthalmol. 1977 Jun;95(6):1041-50. doi: 10.1001/archopht.1977.04450060127013.
Minimal retinal damage in xenon-arc photocoagulation lesions in man 14 hours to three days after exposure was confined to the retinal pigment epithelium (RPE) and consisted of accumulation of lysosome-related bodies in the cytoplasm. Slightly more intense damage consisted of dilation, vacuolization, and breakdown of the lamellae of the smooth-surfaced endoplasmic reticulum, preferentially around melanin-rich cell portions. Underneath more heavily vacuolated cells of the RPE, already in the periphery of ophthalmoscopically just-visible lesions, damage extended into the endothelial cells of the choriocapillaris and into the photoreceptor elements. Macrophages escaped from the choroidal circulation to appear on both sides of the Bruch membrane and within the subretinal space. More intense lesions showed features identical to those described in monkeys and are expected to show the same morphologic pattern of healing.
人类暴露于氙弧光凝损伤后14小时至三天，视网膜的最小损伤局限于视网膜色素上皮（RPE），表现为细胞质中溶酶体相关小体的积累。稍严重的损伤包括光滑内质网板层的扩张、空泡化和破裂，优先发生在富含黑色素的细胞部分周围。在RPE空泡化更严重的细胞下方，即在检眼镜下刚刚可见病变的周边，损伤扩展至脉络膜毛细血管的内皮细胞和光感受器元件。巨噬细胞从脉络膜循环逸出，出现在布鲁赫膜两侧和视网膜下间隙内。更严重的损伤表现出与猴子中描述的特征相同，预计会呈现相同的愈合形态模式。
