Lee E H
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China.
Chin J Physiol. 1995;38(2):125-9.
The present study investigated the role of corticotropin-releasing factor (CRF) in the lateral septum in modulating the memory process and in regulation of the rearing response in rats. Rats were bilaterally cannulated in the lateral septum and CRF was injected right after training of an inhibitory avoidance task. Retention performance and rearing measure were conducted 24 hr later. In another experiment, CRF was also injected into the lateral septum and rearing response measured immediately afterwards. Results indicated that CRF, at moderate doses, markedly enhanced memory retention and decreased rearing response in rats. The latter effect was no longer observed 24 hr after CRF injection. These findings support the notion that the lateral septum is involved in the memory process and emotional expression. These results, together with earlier reports, also suggest that CRF probably produces a consistent facilitatory effect upon memory consolidation and inhibitory effect upon exploration within the limbic system in rats.
本研究调查了大鼠外侧隔区中促肾上腺皮质激素释放因子（CRF）在调节记忆过程及调控竖毛反应中的作用。大鼠双侧外侧隔区插管，在抑制性回避任务训练后立即注射CRF。24小时后进行记忆保持能力测试和竖毛测量。在另一实验中，同样向外侧隔区注射CRF，并随后立即测量竖毛反应。结果表明，中等剂量的CRF显著增强了大鼠的记忆保持能力，并降低了竖毛反应。CRF注射24小时后不再观察到后一种效应。这些发现支持了外侧隔区参与记忆过程和情绪表达的观点。这些结果与早期报告一起还表明，CRF可能对大鼠边缘系统内的记忆巩固产生持续的促进作用，并对探索行为产生抑制作用。
