Fasting and postprandial antroduodenal motility was studied with manometry in 39 patients with functional dyspepsia (FD) and 15 healthy volunteers. The results showed that: (1) the interdigestive antral motility was significantly decreased with contractions of lower amplitude and less frequency and the amplitude of duodenal contractions was significantly lower in patients than that in controls; (2) the patients also had a reduced antroduodenal motor response to a solid-liquid test meal; (3) the number of antroduodenal coordinated contractions was significantly less in patients and motor abnormalities such as duodenal phase III- like bursts and early appearing interdigestive migrating motor complex (MMC) were recorded in a minority of patients.