Haraguchi H, Ohmi I, Masuda H, Tamura Y, Mizutani K, Tanaka O, Chou W H
Faculty of Engineering, Fukuyama University, Japan.
Experientia. 1996 Jun 15;52(6):564-7. doi: 10.1007/BF01969729.
Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.
落新妇苷和新落新妇苷是来自黄杞的二氢黄酮醇鼠李糖苷，它们对晶状体醛糖还原酶表现出强效抑制作用。动力学分析表明，落新妇苷对dl-甘油醛和NADPH均表现出非竞争性抑制作用。这些 taxifolin 糖苷是醛糖还原酶的选择性抑制剂，对NADH氧化酶没有抑制作用。
