Itälä M, Vainio O, Remes K
Turku University Central Hospital, Department of Medicine, Finland.
Eur J Haematol. 1996 Jul;57(1):46-53. doi: 10.1111/j.1600-0609.1996.tb00489.x.
Leukocyte functions were studied in 22 patients with chronic lymphocytic leukaemia (CLL) and were related to the patients' susceptibility to infections. In CLL patients with a history of infections, compared with CLL patients without infections or healthy controls, there were significant impairments of most granulocyte functions; random migration, N-formyl-methionylleucylphenylalanine (fMLP) and C5a stimulated chemotaxis and chemiluminescence response were decreased. No differences in these functions between CLL patients without infections and healthy controls were observed. Phagocytosis and intracellular killing of granulocytes were intact in all patients with CLL. By univariate analysis, neutrophil count and serum IgG level also predicted susceptibility to infections. By multivariate analyses, granulocyte chemotaxis and chemiluminescence remained as statistically significant predictors of infections. The lymphocyte functions (mitogen-induced lymphocyte proliferation and immunoglobulin production in vitro) were equally impaired in all patients with CLL and differed significantly from the respective functions in healthy control subjects. We conclude that impairments in granulocyte functions contribute to susceptibility to infections in CLL.
对22例慢性淋巴细胞白血病（CLL）患者的白细胞功能进行了研究，并将其与患者对感染的易感性相关联。在有感染史的CLL患者中，与无感染的CLL患者或健康对照相比，大多数粒细胞功能存在显著损害；随机迁移、N-甲酰甲硫氨酰亮氨酰苯丙氨酸（fMLP）和C5a刺激的趋化性及化学发光反应均降低。未观察到无感染的CLL患者与健康对照在这些功能上的差异。所有CLL患者的粒细胞吞噬作用和细胞内杀伤功能均正常。单因素分析显示，中性粒细胞计数和血清IgG水平也可预测对感染的易感性。多因素分析表明，粒细胞趋化性和化学发光仍然是感染的统计学显著预测指标。所有CLL患者的淋巴细胞功能（丝裂原诱导的淋巴细胞增殖和体外免疫球蛋白产生）均同样受损，且与健康对照受试者的相应功能有显著差异。我们得出结论，粒细胞功能损害导致CLL患者易发生感染。
