Christensen C L, Gliner J A, Horvath S M, Wagner J A
Aviat Space Environ Med. 1977 Jun;48(6):491-6.
The consequences for vigilance performance of inhaling carbon monoxide at altitude were examined. In addition, the effects of altitude and CO at an equivalent reduction in O2-carrying capacity were compared. Ten subjects performed a visual vigilance task under four atmospheric conditions. Physiological measures included heart rate, blood pressure, and ventilation. Blood hemoglobin and CO levels were measured directly from blood samples drawn after 0,50 and 120 min of exposure. The physiological variables measured and subjective responses of subjects showed no changes attributable to the atmospheric conditions. A statistically significant change in vigilance performance as measured by precentage of signals detected, was found between control and low oxygen; however, performance under CO and the combination of CO and low oxygen was not different from control. The lack of deterioration in performance under the combination of CO and low oxygen suggested that the increased severity of the stress resulted in activation of compensatory mechanisms which counterbalanced the decreased O2 available to the tissues.
研究了在高海拔地区吸入一氧化碳对警觉性表现的影响。此外，还比较了在同等降低携氧能力的情况下，海拔和一氧化碳的影响。10名受试者在四种大气条件下执行视觉警觉任务。生理指标包括心率、血压和通气。在暴露0、50和120分钟后采集血样，直接测量血液中的血红蛋白和一氧化碳水平。所测量的生理变量和受试者的主观反应未显示出可归因于大气条件的变化。通过检测到的信号百分比衡量，在对照和低氧条件下，警觉性表现存在统计学上的显著变化；然而，一氧化碳以及一氧化碳与低氧组合条件下的表现与对照无异。一氧化碳与低氧组合条件下表现未恶化，这表明压力增加的严重性导致了补偿机制的激活，该机制抵消了组织可利用氧气的减少。
