Jelkmann W, Seidl J
Biomed Biochim Acta. 1987;46(2-3):S304-8.
Plasma erythropoietin titers (Ep) were compared in rats subjected to different kinds of systemic hypoxia. Ep increased exponentially, when hypoxia was induced by exposure to simulated altitude (from less than 0.025 IU Ep/ml plasma at sea-level up to 3.65 IU Ep/ml at 7000 m). An acute increase in the O2 affinity of blood augmented Ep production in normal rats but not in rats exposed to hypobaria. Ep also rose exponentially when isovolemic anemia was induced (e.g., 0.5 IU Ep/ml plasma were found at 7 g Hb/dl blood). When the same reduction in blood O2 carrying capacity was produced by CO-inhalation (0.1% CO in air), Ep increased to 5.57 IU/ml plasma. This very high value was considered to be partly due to the very high O2 affinity of carboxyhemoglobin. These results indicate that a left shift in the hemoglobin-O2 dissociation curve produces a stimulation of Ep production, particularly, when the O2-carrying capacity of blood is lowered.
比较了不同类型全身性缺氧大鼠的血浆促红细胞生成素水平（Ep）。当通过暴露于模拟海拔诱导缺氧时（从海平面低于0.025 IU Ep/ml血浆到7000米处的3.65 IU Ep/ml），Ep呈指数增加。血液氧亲和力的急性增加在正常大鼠中增加了Ep的产生，但在低气压环境下的大鼠中则没有。当诱导等容性贫血时（例如，在血红蛋白浓度为7 g Hb/dl血液时发现0.5 IU Ep/ml血浆），Ep也呈指数上升。当通过吸入CO（空气中0.1% CO）使血液携氧能力产生相同程度降低时，Ep增加到5.57 IU/ml血浆。这个非常高的值被认为部分归因于羧基血红蛋白非常高的氧亲和力。这些结果表明，血红蛋白-氧解离曲线的左移会刺激Ep的产生，特别是当血液携氧能力降低时。
