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Combined therapy trial with interferon alpha-2a and ablative therapy in the treatment of anogenital warts.

作者信息

Armstrong D K, Maw R D, Dinsmore W W, Blaakaer J, Correa M A, Falk L, Ferenczy A S, Fortier M, Frazer I, Law C, Moller B M, Oyakawa N

机构信息

Department of Genitourinary Medicine, Royal Victoria Hospital, Belfast.

出版信息

Genitourin Med. 1996 Apr;72(2):103-7. doi: 10.1136/sti.72.2.103.

DOI:10.1136/sti.72.2.103
PMID:8698355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1195617/
Abstract

OBJECTIVE

To determine whether the combination of systemically administered interferon alpha-2a and ablative surgery for the treatment of genital and/or perianal warts produces a 30% or greater improvement in lasting response rate compared with a control group receiving a combination of placebo and ablative therapy.

DESIGN

Randomised, triple-blind, placebo-controlled trial using 1 or 3 MIU of interferon alpha-2a or placebo administered subcutaneously three times weekly for 10 weeks in combination with ablative surgery.

SETTING

International, multicentre study in 10 genitourinary medicine clinics.

PATIENTS

Two hundred and fifty patients with anogenital warts.

MAIN OUTCOME MEASURES

Lasting response at week 38.

RESULTS

Standard efficacy analysis at week 38 showed a lasting response in 51% (35/68) of 3 MIU interferon-treated patients, 48% (30/63) of 1 MIU interferon-treated patients and 43% (29/67) of placebo-treated patients.

CONCLUSIONS

With the doses and regime described, treatment with interferon alpha-2a in combination with ablative therapy is not significantly superior in the treatment of anogenital warts than placebo and ablative therapy.

摘要

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本文引用的文献

1
A randomised, double-blind, parallel group study to compare subcutaneous interferon alpha-2a plus podophyllin with placebo plus podophyllin in the treatment of primary condylomata acuminata.
Genitourin Med. 1994 Dec;70(6):389-93. doi: 10.1136/sti.70.6.389.
2
Treatment of anogenital warts. Comparison of trichloracetic acid and podophyllin versus podophyllin alone.
Br J Vener Dis. 1983 Apr;59(2):124-6. doi: 10.1136/sti.59.2.124.
3
Interferon therapy for condylomata acuminata.
N Engl J Med. 1986 Oct 23;315(17):1059-64. doi: 10.1056/NEJM198610233151704.
4
Treatment of condyloma acuminatum with three different interferons administered intralesionally. A double-blind, placebo-controlled trial.
Ann Intern Med. 1988 May;108(5):675-9. doi: 10.7326/0003-4819-108-5-675.
5
Natural interferon alfa for treatment of condylomata acuminata.
JAMA. 1988;259(4):533-8.
6
Efficacy of human lymphoblastoid interferon in the therapy of resistant condyloma acuminata.
Obstet Gynecol. 1986 May;67(5):643-51. doi: 10.1097/00006250-198605000-00008.
7
Latent papillomavirus and recurring genital warts.
N Engl J Med. 1985 Sep 26;313(13):784-8. doi: 10.1056/NEJM198509263131304.
8
Tolerance and efficacy of recombinant human interferon gamma in the treatment of refractory genital warts.
Am J Med. 1988 Aug;85(2):183-8. doi: 10.1016/s0002-9343(88)80339-5.
9
A randomized trial of combination therapy with intralesional interferon alpha 2b and podophyllin versus podophyllin alone for the therapy of anogenital warts.
J Infect Dis. 1990 Jul;162(1):52-9. doi: 10.1093/infdis/162.1.52.
10
Treatment of external genital warts: a randomised clinical trial comparing podophyllin, cryotherapy, and electrodesiccation.
Genitourin Med. 1990 Feb;66(1):16-9. doi: 10.1136/sti.66.1.16.

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