外生殖器疣的治疗：一项比较鬼臼树脂、冷冻疗法和电干燥法的随机临床试验。
Treatment of external genital warts: a randomised clinical trial comparing podophyllin, cryotherapy, and electrodesiccation.
作者信息
Stone K M, Becker T M, Hadgu A, Kraus S J
机构信息
Division of Sexually Transmitted Diseases Centers for Disease Control, Atlanta, Georgia.
出版信息
Genitourin Med. 1990 Feb;66(1):16-9. doi: 10.1136/sti.66.1.16.
Abstract
Four hundred and fifty patients were enrolled into a randomised clinical trial in a public sexually transmitted diseases clinic to evaluate the efficacy of podophyllin, cryotherapy, and electrodesiccation for treatment of external genital warts. Complete clearance of warts was observed in 41%, 79%, and 94% of patients who received up to six weekly treatments of podophyllin, cryotherapy, and electrodesiccation, respectively. Relapses occurred in 25% of all patients, yielding 3 month clearance rates of 17%, 55%, and 71% for podophyllin, cryotherapy, and electrodesiccation, respectively. Wart volume and duration did not influence treatment outcome. Response to therapy was greater in women than in men, and did not differ by treatment modality. Electrodesiccation and cryotherapy were more effective than podophyllin for the treatment of external genital warts, but none of these three treatments were highly successful.
摘要
450名患者被纳入一家公共性传播疾病诊所的一项随机临床试验，以评估鬼臼树脂、冷冻疗法和电干燥法治疗外生殖器疣的疗效。分别接受多达六周每周一次鬼臼树脂、冷冻疗法和电干燥法治疗的患者中，疣完全清除的比例分别为41%、79%和94%。所有患者中有25%出现复发，鬼臼树脂、冷冻疗法和电干燥法的3个月清除率分别为17%、55%和71%。疣体大小和病程不影响治疗结果。女性对治疗的反应比男性更好，且不同治疗方式之间无差异。电干燥法和冷冻疗法在外生殖器疣的治疗上比鬼臼树脂更有效，但这三种治疗方法均未取得很高的成功率。
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