小鼠卡氏肺孢子虫肺炎中肺泡巨噬细胞来源的多核巨细胞的T细胞和B细胞非依赖性形成
T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia.
作者信息
Hanano R, Reifenberg K, Kaufmann S H
机构信息
Department of Immunology, University of Ulm, Germany.
出版信息
Infect Immun. 1996 Jul;64(7):2821-3. doi: 10.1128/iai.64.7.2821-2823.1996.
Abstract
Multinucleated giant cells developed in Pneumocystis carinii-diseased gene disruption mutant mice deficient in major histocompatibility complex class II molecules, T-cell receptor alpha beta cells, or all mature T and B lymphocytes. These findings demonstrate lymphocyte-independent fusion of alveolar macrophages under morbid conditions. Pulmonary parasite burden seems to be a decisive factor in multinucleation.
摘要
在主要组织相容性复合体II类分子、T细胞受体αβ细胞或所有成熟T和B淋巴细胞缺陷的卡氏肺孢子虫病基因破坏突变小鼠中出现了多核巨细胞。这些发现表明，在病态条件下肺泡巨噬细胞可发生不依赖淋巴细胞的融合。肺部寄生虫负荷似乎是多核化的决定性因素。
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