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Nitric oxide production and mycobacterial growth inhibition by murine alveolar macrophages: the sequence of rIFN-gamma stimulation and Mycobacterium bovis BCG infection determines macrophage activation.

作者信息

Hanano R, Kaufmann S H

机构信息

Department of Immunology, University of Ulm, Germany.

出版信息

Immunol Lett. 1995 Feb;45(1-2):23-7. doi: 10.1016/0165-2478(94)00193-u.

DOI:10.1016/0165-2478(94)00193-u
PMID:7622183
Abstract

Prestimulation with recombinant-interferon-gamma (rIFN-gamma) followed by Mycobacterium bovis BCG infection induced high nitric oxide production and potent mycobacterial growth inhibition in murine alveolar macrophages. Reversal of the sequence of treatments caused opposite effects, suggesting that a sequential 2-step process comprising first rIFN-gamma stimulation and second mycobacterial infection is operative in the activation of alveolar macrophages.

摘要

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