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本文引用的文献

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Biology of the multidrug resistance-associated protein, MRP.多药耐药相关蛋白MRP的生物学特性
Eur J Cancer. 1996 Jun;32A(6):945-57. doi: 10.1016/0959-8049(96)00046-9.
2
Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines.对一种新的假定跨膜药物转运蛋白基因MRP在人多药耐药肺癌细胞系中的表达分析。
Cancer Res. 1993 Apr 15;53(8):1747-50.
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Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.一种新型多药耐药相关基因在HT1080/DR4和H69AR人肿瘤细胞系中的定位。
Cancer Res. 1993 Jul 15;53(14):3221-5.
4
Brefeldin A protects ricin-induced cytotoxicity in human cancer KB cell line, but not in its resistant counterpart with altered Golgi structures.布雷菲德菌素A可保护人癌细胞KB细胞系免受蓖麻毒素诱导的细胞毒性，但对高尔基体结构改变的耐药细胞系则无效。
Cell Struct Funct. 1993 Aug;18(4):241-51. doi: 10.1247/csf.18.241.
5
Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.多药耐药相关蛋白（MRP）的过表达会增加对天然产物药物的耐药性。
Cancer Res. 1994 Jan 15;54(2):357-61.
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Expression complementary DNA library transfer establishes mrp as a multidrug resistance gene.表达互补DNA文库转移确定mrp为多药耐药基因。
Cancer Res. 1994 Apr 1;54(7):1649-52.
7
Biochemistry of multidrug resistance mediated by the multidrug transporter.多药转运蛋白介导的多药耐药的生物化学
Annu Rev Biochem. 1993;62:385-427. doi: 10.1146/annurev.bi.62.070193.002125.
8
The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.与非P-糖蛋白多药耐药相关的MRP基因编码一种190 kDa的膜结合糖蛋白。
Cancer Res. 1993 Aug 15;53(16):3658-61.
9
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.MRP基因编码一种针对白三烯C4及结构相关共轭物的ATP依赖性外排泵。
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10
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.多药耐药的MRP转染人肿瘤细胞的药理学特性
Cancer Res. 1994 Nov 15;54(22):5902-10.

在对表鬼臼毒素产生耐药性的人癌细胞系中多药耐药蛋白基因的过表达。

Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins.

作者信息

Koike K, Abe T, Hisano T, Kubo T, Wada M, Kohno K, Kuwano M

机构信息

Department of Biochemistry, Kyushu University School of Medicine, Fukuoka.

出版信息

Jpn J Cancer Res. 1996 Jul;87(7):765-72. doi: 10.1111/j.1349-7006.1996.tb00290.x.

DOI:10.1111/j.1349-7006.1996.tb00290.x
PMID:8698628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5921162/
Abstract

Overexpression of either the multidrug resistance 1 (MDR1) gene or multidrug resistance protein (MRP) gene is involved in acquisition of multidrug-resistant phenotypes in human cancer cells. In this study we examined whether selection for resistance to the epipodophyllotoxins, etoposide/teniposide (VP16/VM26), could induce overexpression of MDR1 or MRP. We have previously isolated two VP16/VM26-resistant KB cell lines. Two VP16/VM26-resistant KB cell lines, KB/VM-1 and KB/ VM-4, which were selected by stepwise exposure to VM26 had decreased accumulation of [3H]VP16 and increased levels of MRP, but no apparent expression of MDR1 gene was observed. Another VP16/VM26-resistant KB cell line, KB/VP-4, which was further isolated from a VP16-resistant KB cell line, KB/VP-2, had decreased accumulation of [3H]VP16 and showed overexpression of MRP gene, but not that of MDR1 gene. We also isolated a VP16-resistant cell line, IN157/VP-1, from a human glioma cell line IN157. IN157/VP-1 cells showed decreased accumulation of [3H]VP16 and overexpression of MRP gene, but not of MDR1. These findings suggest that selection for resistance to VP16/VM26, preferentially induces overexpression of MRP gene.

摘要

多药耐药1（MDR1）基因或多药耐药蛋白（MRP）基因的过表达与人类癌细胞多药耐药表型的获得有关。在本研究中，我们检测了对表鬼臼毒素、依托泊苷/替尼泊苷（VP16/VM26）的耐药性选择是否能诱导MDR1或MRP的过表达。我们之前分离出了两个对VP16/VM26耐药的KB细胞系。通过逐步暴露于VM26筛选出的两个对VP16/VM26耐药的KB细胞系，KB/VM-1和KB/VM-4，其[3H]VP16的蓄积减少，MRP水平升高，但未观察到MDR1基因的明显表达。另一个对VP16/VM26耐药的KB细胞系，KB/VP-4，是从对VP16耐药的KB细胞系KB/VP-2中进一步分离得到的，其[3H]VP16的蓄积减少，显示出MRP基因的过表达，但未显示MDR1基因的过表达。我们还从人胶质瘤细胞系IN157中分离出了一个对VP16耐药的细胞系，IN157/VP-1。IN157/VP-1细胞显示[3H]VP16的蓄积减少，MRP基因过表达，但MDR基因未过表达。这些发现表明，对VP16/VM26的耐药性选择优先诱导MRP基因的过表达。