曲霉糖苷，一种来自双毛曲霉的新型抗真菌剂。I. 分类学、发酵及生物活性。

Ascosteroside, a new antifungal agent from Ascotricha amphitricha. I. Taxonomy, fermentation and biological activities.

作者信息

Gorman J A, Chang L P, Clark J, Gustavson D R, Lam K S, Mamber S W, Pirnik D, Ricca C, Fernandes P B, O'Sullivan J

机构信息

Department of Microbial Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, USA.

出版信息

J Antibiot (Tokyo). 1996 Jun;49(6):547-52. doi: 10.7164/antibiotics.49.547.

DOI:10.7164/antibiotics.49.547

PMID:8698637

Abstract

Ascosteroside, a novel antifungal compound, was isolated from the culture broth of Ascotricha amphitricha. This compound is an alpha-linked glycoside of a lanostane type triterpenoid. It is active against yeasts such as Candida albicans and Saccharomyces cerevisiae and against filamentous fungi but shows no activity against bacteria. It is not toxic to mammalian cells at concentrations up to 150 microM. In a mouse model, the compound afforded protection comparable to that of ketoconazole.

摘要

从双端枝孢菌（Ascotricha amphitricha）的培养液中分离出了一种新型抗真菌化合物——曲霉糖苷。该化合物是羊毛甾烷型三萜的α-连接糖苷。它对白色念珠菌（Candida albicans）和酿酒酵母（Saccharomyces cerevisiae）等酵母以及丝状真菌具有活性，但对细菌无活性。在浓度高达150微摩尔时，它对哺乳动物细胞无毒。在小鼠模型中，该化合物提供了与酮康唑相当的保护作用。