Gerth K, Bedorf N, Höfle G, Irschik H, Reichenbach H
GBF, Gesellschaft für Biotechnologische Forschung, Abteilung Naturstoffbiologie, Braunschweig, Federal Republic of Germany.
J Antibiot (Tokyo). 1996 Jun;49(6):560-3. doi: 10.7164/antibiotics.49.560.
An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum (Myxococcales) strain So ce90. The activity was excreted into the supernatant during the log and early stationary phase. When the adsorber resin XAD-16 was added to the culture, the active metabolites were quantitatively bound to the resin. The epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol (BOLLAG et al., Cancer Res. 55: 2325 approximately 2333, 1995).
在纤维堆囊菌（粘球菌目）菌株So ce90的培养液中检测到了对冬生毛霉的抗真菌活性。该活性在对数期和稳定期早期分泌到上清液中。当向培养物中加入吸附树脂XAD - 16时，活性代谢产物被定量地结合到树脂上。埃坡霉素对动物细胞显示出高细胞毒性，并模拟了紫杉醇的生物学效应（博拉格等人，《癌症研究》55: 2325至2333，1995年）。
