Trivedi M H
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA.
J Clin Psychiatry. 1996;57 Suppl 8:26-35; discussion 36.
Although obsessive-compulsive disorder (OCD) was once considered rare, recent epidemiologic data suggest a lifetime prevalence rate of 2% to 3%. The morbidity associated with OCD is quite high compared to other psychiatric conditions. This report reviews neurologic, neuropsychological, and psychosurgical findings relevant to the functional neuroanatomy of OCD. In addition, it describes more recent investigations of OCD using a variety of brain imaging techniques, including computed tomography, positron emission tomography, and single photon emission computed tomography (SPECT). Finally, it examines the results of an ongoing pilot study of high-resolution, full-volume, three-dimensional SPECT imaging in patients with OCD before and after treatment with fluvoxamine.
尽管强迫症（OCD）曾被认为较为罕见，但近期的流行病学数据显示其终生患病率为2%至3%。与其他精神疾病相比，强迫症的发病率相当高。本报告回顾了与强迫症功能神经解剖学相关的神经学、神经心理学和精神外科研究结果。此外，还描述了使用多种脑成像技术对强迫症进行的最新研究，这些技术包括计算机断层扫描、正电子发射断层扫描和单光子发射计算机断层扫描（SPECT）。最后，研究了一项正在进行的关于强迫症患者在接受氟伏沙明治疗前后进行高分辨率、全容积、三维SPECT成像的初步研究结果。
