Richert S, Bloom E J, Flynn K, Seraly M P
Department of Dermatology, University of Pittsburgh Medical Center, PA, USA.
J Am Acad Dermatol. 1996 Aug;35(2 Pt 2):326-9. doi: 10.1016/s0190-9622(96)90661-1.
Eruptive nevi have been associated with local skin trauma and immunosuppression, and atypical eruptive nevi preceding melanoma have been reported in immunocompromised transplant patients. We describe a 25-year-old man with widespread eruptive atypical and dermal melanocytic nevi in association with chronic myelocytic leukemia. Our patient's disease differs from earlier reports of eruptive nevi because his nevi appeared before induction chemotherapy. Eruptive nevi may have been a prodrome to leukemia in this patient. His nevi were histologically similar to eruptive atypical nevi observed in AIDS patients and may imply a link between systemic immunosuppression and melanocyte proliferation. We suggest that patients in whom eruptive nevi develop in association with immunosuppression should be carefully observed for the development of melanoma skin cancer.
发疹性痣与局部皮肤创伤及免疫抑制有关，免疫功能低下的移植患者中曾有黑色素瘤之前出现非典型发疹性痣的报道。我们描述了一名25岁男性，其患有广泛的发疹性非典型真皮黑素细胞痣，并伴有慢性粒细胞白血病。我们患者的病情与早期发疹性痣的报道不同，因为他的痣在诱导化疗之前就已出现。发疹性痣可能是该患者白血病的前驱症状。他的痣在组织学上与艾滋病患者中观察到的发疹性非典型痣相似，这可能意味着全身免疫抑制与黑素细胞增殖之间存在联系。我们建议，对于伴有免疫抑制而出现发疹性痣的患者，应密切观察是否发生皮肤黑色素瘤。
