Dertlioglu Selma Bakar, Bitiren Muharrem, Cicek Demet
Department of Dermatology, Harran University Faculty of Medicine, Firat University Faculty of Medicine, Turkey .
Indian J Dermatol. 2011 Nov;56(6):737-9. doi: 10.4103/0019-5154.91842.
An 8-year-old male patient who had been diagnosed as acute lymphoblastic leukemia (ALL) 4 years ago and received 120 cures of chemotherapy presented at our clinic complaining of spots on his body 3 months after the end of chemotherapy. Anamnesis of the patient revealed that the lesions started 3 months after the last cure of chemotherapy on the abdomen and spread throughout the body. It was learnt that the number of spots increased very rapidly in a period of 2 months, and exceeded 100. A dermatological examination of the patient showed 142 hyperpigmented macules, the largest of which was 1 cm × 1 cm and the smallest was 0.2 cm × 0.2 cm in size, diffusely scattered to the skin and oral mucosa. When the biopsy material taken from the lesions was histopathologically examined, nest structures composed of nevus cells with oval nuclei and eosinophilic cytoplasm starting from the dermoepidermal junction and extending toward the lower epidermis were observed and found to be consistent with the compound nevus. We present this rare case who was diagnosed as "eruptive compound nevus" on the basis of clinical signs, ALL diagnosis, chemotherapy history and histopathologic evaluation.
一名8岁男性患者，4年前被诊断为急性淋巴细胞白血病（ALL），接受了120次化疗疗程，化疗结束3个月后到我院门诊就诊，主诉身上出现斑点。患者的既往史显示，病变在最后一次化疗疗程结束3个月后始于腹部，并蔓延至全身。据悉，斑点数量在2个月内迅速增加，超过了100个。对该患者进行皮肤科检查发现142个色素沉着斑，最大的为1 cm×1 cm，最小的为0.2 cm×0.2 cm，散在分布于皮肤和口腔黏膜。对病变部位取活检材料进行组织病理学检查时，观察到由痣细胞组成的巢状结构，其细胞核呈椭圆形，细胞质嗜酸性，从真皮表皮交界处开始并向下延伸至表皮，结果发现与复合痣相符。我们根据临床体征、ALL诊断、化疗史和组织病理学评估，报告这例被诊断为“发疹性复合痣”的罕见病例。
