King R, Gough J, Ronald A, Nasio J, Ndinya-Achola J O, Plummer F, Wilkins J A
Department of Pathology, University of Manitoba, Winnipeg, Canada.
J Infect Dis. 1996 Aug;174(2):427-30. doi: 10.1093/infdis/174.2.427.
Haemophilus ducreyi is a major cause of genital ulcer disease in many developing countries and is associated with augmented transmission of human immunodeficiency virus (HIV). However, the mechanisms through which H. ducreyi produces ulceration are poorly understood. The characteristics of the host response to H. ducreyi and the pathobiology of its potential contribution to increased HIV susceptibility are not known. Chancroid ulcer biopsies from 8 patients were analyzed histologically and immunohistochemically. All biopsies had perivascular and interstitial mononuclear cell infiltrates that extended deep into the dermis. The infiltrate, which contained macrophages and CD4 and CD8 lymphocytes, was consistent with a delayed hypersensitivity type cell-mediated immune response. The recruitment of CD4 T lymphocytes and macrophages may in part explain the facilitation of HIV transmission in patients with chancroid.
杜克雷嗜血杆菌是许多发展中国家生殖器溃疡疾病的主要病因，并且与人类免疫缺陷病毒（HIV）传播增加有关。然而，杜克雷嗜血杆菌导致溃疡形成的机制尚不清楚。宿主对杜克雷嗜血杆菌的反应特征及其对HIV易感性增加的潜在病理生物学机制尚不清楚。对8例软下疳溃疡活检组织进行了组织学和免疫组织化学分析。所有活检组织均有血管周围和间质单核细胞浸润，浸润深入真皮深层。浸润细胞包括巨噬细胞、CD4和CD8淋巴细胞，符合迟发型超敏反应型细胞介导的免疫反应。CD4 T淋巴细胞和巨噬细胞的募集可能部分解释了软下疳患者中HIV传播的促进作用。
