Magro C M, Crowson A N, Alfa M, Nath A, Ronald A, Ndinya-Achola J O, Nasio J
Department of Pathology, Beth Israel Hospital, Harvard Medical School, Boston, MA, USA.
Hum Pathol. 1996 Oct;27(10):1066-70. doi: 10.1016/s0046-8177(96)90285-3.
Chancroid, the most common cause of genital ulceration in Africa, is known to be associated epidemiologically with heterosexual transmission of human immunodeficiency virus (HIV). The pathophysiological mechanisms by which chancroid might facilitate the spread of HIV are obscure. To investigate the role of chancroid in HIV transmission, the authors studied the histological features of biopsies from 11 men with penile chancroid lesions including five who were serologically positive for HIV. The histomorphologic and immunophenotypic nature of the inflammatory infiltrates suggests that there is a significant role for cell-mediated immunity in the host response to Hemophilus ducreyi infection. This response may be critical to the role of chancroid in HIV transmission.
软下疳是非洲生殖器溃疡最常见的病因，已知在流行病学上与人类免疫缺陷病毒（HIV）的异性传播有关。软下疳促进HIV传播的病理生理机制尚不清楚。为了研究软下疳在HIV传播中的作用，作者研究了11例患有阴茎软下疳病变男性的活检组织学特征，其中5例HIV血清学检测呈阳性。炎症浸润的组织形态学和免疫表型特征表明，细胞介导的免疫在宿主对杜克雷嗜血杆菌感染的反应中起重要作用。这种反应可能对软下疳在HIV传播中的作用至关重要。
