肌腱中蛋白聚糖的含量及胶原蛋白的轴向周期性。
The proteoglycan content and the axial periodicity of collagen in tendon.
作者信息
Gillard G C, Merrilees M J, Bell-Booth P G, Reilly H C, Flint M H
出版信息
Biochem J. 1977 Apr 1;163(1):145-51. doi: 10.1042/bj1630145.
The glycosaminoglycan content and the axial periodicity of collagen was determined in various regions of the rabbit flexor digitorum profundus tendon. This tendon, which passes from the calf to the toes round the inner side of the ankle, contains a thickened sesamoid-like pad where it is subjected to friction and pressure. Other regions of the tendon are subject only to longitudinal tension. In tensional areas the axial periodicity of collagen was of the order of 62 nm and the tissue contained less than 0.2% proteoglycan on a dry weight basis. In the sesamoid-like region, however, the axial periodicity was a significant 13-15% less, and the proteoglycan constituted about 3.5% of the dry weight. Also, in the tensional areas the predominant glycosaminoglycan was dermatan sulphate, whereas in the sesamoid the predominant glycosaminoglycan was chondroitin sulphate. The possible interrelationships between collagen axial peroidicity and proteoglycan content in this tissue are discussed.
测定了兔趾深屈肌腱不同区域的糖胺聚糖含量和胶原蛋白的轴向周期性。该肌腱从小腿经脚踝内侧延伸至脚趾，在受到摩擦和压力的部位含有一个增厚的籽骨样垫。肌腱的其他区域仅承受纵向拉力。在受拉区域，胶原蛋白的轴向周期性约为62纳米，按干重计算，组织中蛋白聚糖含量低于0.2%。然而，在籽骨样区域，轴向周期性显著减少了13 - 15%，蛋白聚糖占干重的约3.5%。此外，在受拉区域，主要的糖胺聚糖是硫酸皮肤素，而在籽骨中主要的糖胺聚糖是硫酸软骨素。本文讨论了该组织中胶原蛋白轴向周期性与蛋白聚糖含量之间可能的相互关系。
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