BASSETT C A, BECKER R O
Science. 1962 Sep 28;137(3535):1063-4. doi: 10.1126/science.137.3535.1063.
The amplitude of electrical potentials generated in stressed bone is dependent upon the rate and magnitude of bony deformation, while polarity is determined by the direction of bending. Areas under compression develop negative potentials with respect to other areas. Similar results were obtained both in living and dead bone. Removal of the inorganic fraction from bone abolishes its ability to generate stress potentials. It is probable that these potentials influence the activity of osseous cells directly. Furthermore, it is conceivable that they may direct, in some manner, the aggregation pattern of the macromolecules of the extracellular matrix.
应力作用下骨骼产生的电位幅度取决于骨变形的速率和大小，而极性则由弯曲方向决定。受压区域相对于其他区域产生负电位。在活骨和死骨中均获得了类似结果。去除骨中的无机成分会消除其产生应力电位的能力。这些电位很可能直接影响骨细胞的活性。此外，可以想象它们可能以某种方式指导细胞外基质大分子的聚集模式。
