神经营养因子-3抗体破坏雏鸡视网膜的正常发育。
Neurotrophin-3 antibodies disrupt the normal development of the chick retina.
作者信息
Bovolenta P, Frade J M, Martí E, Rodríguez-Peña M A, Barde Y A, Rodríguez-Tébar A
机构信息
Cajal Institute, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
出版信息
J Neurosci. 1996 Jul 15;16(14):4402-10. doi: 10.1523/JNEUROSCI.16-14-04402.1996.
Abstract
When chick embryos are treated with a monoclonal antibody specifically blocking the activity of neurotrophin-3 (NT-3), the development of the retina is profoundly affected. Fewer axons are found in the optic nerve, and the retina shows abnormalities in all layers. Early during retinogenesis, the proportion of dividing cells is higher in NT-3-deprived embryos compared with age-matched controls and that of differentiated neurons is smaller. The NT-3 receptor trkC is expressed early by a majority of retinal cells, and NT-3 is present in the retina at the earliest stage studied. Initially, it is located mainly in the pigmented epithelium, with a shift toward the neural retina as development proceeds. Thus, NT-3 seems to be an essential intrinsic signal acting early in development to promote the differentiation and survival of many retinal neurons.
摘要
当用特异性阻断神经营养因子-3（NT-3）活性的单克隆抗体处理鸡胚时，视网膜的发育会受到深远影响。视神经中发现的轴突较少，并且视网膜各层均显示出异常。在视网膜发生早期，与年龄匹配的对照相比，NT-3缺乏的胚胎中分裂细胞的比例更高，而分化神经元的比例更小。NT-3受体trkC在大多数视网膜细胞中早期表达，并且在所研究的最早阶段视网膜中就存在NT-3。最初，它主要位于色素上皮中，随着发育进行向神经视网膜转移。因此，NT-3似乎是一种重要的内在信号，在发育早期起作用以促进许多视网膜神经元的分化和存活。
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