类风湿关节炎中HLA - Cw3和HLA - Dw4频率增加。
Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis.
作者信息
McMichael A J, Sasazuki T, McDevitt H O, Payne R O
出版信息
Arthritis Rheum. 1977 Jun;20(5):1037-42. doi: 10.1002/art.1780200501.
PMID:869952
Abstract
Thirty-nine patients with rheumatoid arthritis were HLA typed for the full range of A and B locus specificities and for Cw3 and Dw4. HLA-Dw4 was significantly more frequent in patients (36%) than in controls (13%). The frequency of Cw3 was also increased, probably because this allele is in linkage disequilibrium with Dw4.
摘要
对39例类风湿性关节炎患者进行了HLA A和B位点全部特异性以及Cw3和Dw4分型。患者中HLA - Dw4的频率（36%）显著高于对照组（13%）。Cw3的频率也有所增加，可能是因为该等位基因与Dw4处于连锁不平衡状态。
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