Bernstein B, Forrester D, Singsen B, King K K, Kornreich H, Hanson V
Arthritis Rheum. 1977 Jun;20(5):1099-104. doi: 10.1002/art.1780200509.
Six children with long-standing juvenile rheumatoid arthritis and radiographic evidence of severe hip joint damage were found 6 months to 5 years afterward to have radiographic evidence of significant hip joint space widening and remodeling of articular surfaces. The disease activity had decreased and hip joint function had improved in all children. Each child had received various antiinflammatory drugs, but no specific medication could be implicated in the improvement. Evidence from animal studies suggests that intensive physical therapy with emphasis on continued weight bearing may have been important in promoting healing in these children. It appears that restoration of severely damaged hip joints in JRA can occur when the disease activity is controlled. Restoration may be favored by a child's greater potential for bone remodeling and by vigorous physical therapy with emphasis upon continued ambulation.
6名患有长期幼年型类风湿关节炎且有严重髋关节损伤影像学证据的儿童，在6个月至5年后被发现有髋关节间隙明显增宽及关节面重塑的影像学证据。所有儿童的疾病活动度均降低，髋关节功能有所改善。每个儿童都接受过各种抗炎药物治疗，但无法确定是哪种特定药物导致了这种改善。动物研究的证据表明，强调持续负重的强化物理治疗可能对促进这些儿童的康复很重要。看来，当疾病活动得到控制时，幼年型类风湿关节炎中严重受损的髋关节可能会恢复。儿童更大的骨重塑潜力以及强调持续行走的积极物理治疗可能有利于恢复。
