Watanabe T, Kasai T, Arima M, Okumura K, Kawabe N, Hirayama T
Kyoto Pharmaceutical University, Japan.
Mutat Res. 1996 Jul 10;369(1-2):75-80. doi: 10.1016/s0165-1218(96)90050-6.
The genotoxicity and DNA-damaging activity of 6 phenazine and aminophenazine derivatives were assayed in the wing spot and DNA-repair tests in Drosophila melanogaster. Phenazine (Pz), and all aminophenazines tested, namely, 1-aminophenazine (APz), 2-APz, 2,3-diaminophenazine (DAPz), 2,7-DAPz and 2,7-diamino-3,8-dimethylphenazine (DADMPz), exhibited mutagenicity significantly in the wing spot test. The activities in the wing spot test were ranked in a sequence DADMPz > (2,7-DAPz, 2,3-DAPz) > (2-APz, 1-APz, Pz). In the DNA-repair test, 2,3-DAPz, 2,7-DAPz, and DADMPz clearly showed DNA-damaging activity, but Pz, 1-APz and 2-APz were inactive. Based on these results, we predict that DADMPz, 2,3-DAPz and 2,7-DAPz are likely to be more carcinogenic than 2-APz, 1-APz or Pz.
在黑腹果蝇的翅斑试验和DNA修复试验中，检测了6种吩嗪和氨基吩嗪衍生物的遗传毒性及DNA损伤活性。吩嗪（Pz）以及所有测试的氨基吩嗪，即1-氨基吩嗪（APz）、2-APz、2,3-二氨基吩嗪（DAPz）、2,7-DAPz和2,7-二氨基-3,8-二甲基吩嗪（DADMPz），在翅斑试验中均表现出显著的致突变性。翅斑试验中的活性排序为：DADMPz >（2,7-DAPz，2,3-DAPz）>（2-APz，1-APz，Pz）。在DNA修复试验中，2,3-DAPz、2,7-DAPz和DADMPz明显表现出DNA损伤活性，但Pz、1-APz和2-APz无活性。基于这些结果，我们预测DADMPz、2,3-DAPz和2,7-DAPz可能比2-APz、1-APz或Pz具有更强的致癌性。
