Odutuga A A
Biochim Biophys Acta. 1977 Apr 26;487(1):1-9. doi: 10.1016/0005-2760(77)90038-8.
Rats were made visibly deficient in essential fatty acids by feeding a deficient diet and were then fed a diet containing 5.0 per cent by weight corn oil as a source of essential fatty acids. After 11-13 weeks on deficient diet the weights of the brain were 25% less than those of rats on control diets. After 5 weeks on the control diet, deficient animals had regained normal brain weight and composition and had lost the deficiency symptoms. Lipids were extracted from the brains and analysed qualitatively and quantitatively, the overall effect of essential fatty acid deficiency being a reduction in the proportion of cerebrosides and sphingomyelin, the appearance of a high proportion of eicosatrienoic acid (20:3) and the reduction of arachidonic acid (20: 4) and the other essential fatty acids. It is considered that essential fatty acid deficiency retards maturing of brains and the present data show that this effect is reversible.
通过喂食缺乏必需脂肪酸的饲料使大鼠明显缺乏必需脂肪酸，然后给它们喂食含有5.0%（重量）玉米油作为必需脂肪酸来源的饲料。在缺乏必需脂肪酸的饲料喂养11 - 13周后，大脑重量比对照饲料喂养的大鼠轻25%。在对照饲料喂养5周后，缺乏必需脂肪酸的动物恢复了正常的大脑重量和组成，并消除了缺乏症状。从大脑中提取脂质并进行定性和定量分析，必需脂肪酸缺乏的总体影响是脑苷脂和鞘磷脂比例降低，二十碳三烯酸（20:3）比例升高，花生四烯酸（20:4）和其他必需脂肪酸减少。据认为，必需脂肪酸缺乏会阻碍大脑成熟，目前的数据表明这种影响是可逆的。
