Nagase H, Bray G A, York D A
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Physiol Behav. 1996 Mar;59(3):555-60. doi: 10.1016/0031-9384(95)02109-4.
We have investigated the effects of peripherally administered pyruvate and lactate on the intake of high fat (HF) and low fat (LF) diets by a strain of rat either sensitive (Osborne-Mendel, OM) or resistant (SSB/Pl) to high fat-induced obesity. Both pyruvate and lactate inhibited the intake of HF and LF diets by OM rats and these effects were blocked by selective hepatic vagotomy. In contrast, in S5B/Pl rats fed an LF diet the responses to pyruvate and lactate were attenuated and were absent in S5B/Pl rats fed the HF diet. These data suggest that OM and S5B/Pl rats differ either in their metabolism of pyruvate and lactate or in their responses to these metabolites.
我们研究了外周给予丙酮酸和乳酸对一组易患（奥斯本-孟德尔大鼠，OM）或抗患（SSB/Pl）高脂诱导肥胖的大鼠品系摄入高脂（HF）和低脂（LF）饮食的影响。丙酮酸和乳酸均抑制OM大鼠摄入HF和LF饮食，并且这些作用被选择性肝迷走神经切断所阻断。相反，在喂食LF饮食的S5B/Pl大鼠中，对丙酮酸和乳酸的反应减弱，而在喂食HF饮食的S5B/Pl大鼠中则没有反应。这些数据表明，OM和S5B/Pl大鼠在丙酮酸和乳酸的代谢或对这些代谢产物的反应方面存在差异。
