Nishisaka S, Utoguchi K, Mizoue T, Tokui N, Ogimoto I, Ikeda M, Yoshimura T
Department of Clinical Epidemiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
J UOEH. 1996 Jun 1;18(2):119-31. doi: 10.7888/juoeh.18.119.
This study aims to examine whether self-rated health is an independent predictor of cause-specific mortality even after the influence by a variety of factors in relation to mortality reported by previous studies have been excluded. This study included randomly selected 4,259 inhabitants (1,827 men and 2,432 women) in Y city, Fukuoka prefecture, Japan, aged from 30 to 79 in 1987. These subjects were surveyed in 1987 by self-administered questionnaires regarding self-rated health as well as life habits, and followed up for their vital status and underlying causes of death. After excluding the individuals who were lost to follow up or who didn't respond to the question on self-rated health, 4,046 individuals were analysed to see the relationship between self-rated health and cause-specific mortality by Cox proportional hazard models, controlling for sex, age, smoking, BMI, medical care use and ADL. It was shown that relative risks for all causes, cancer, circulatory disease and other causes among the unhealthy group were 2.95 (95% CI: 1.93-4.50), 2.96 (1.53-5.73), 2.32 (0.86-6.26) and 4.09 (2.12-7.89), relatively. In the analyses of the subgroup (subjects without diseases in 1987 or subjects excluding deceased cases within first 3 years after follow-up), to avoid selection bias, the association between self-rated health and mortality was substantially similar to the results obtained in the former analysis, even the association was weakened. Even after excluding both of the subjects with diseases in 1987 and the subjects who died in the first 3 years after follow-up, self-rated health could be associated with mortality from all causes (RR = 1.89, 95%CI; 0.91-3.94). From the results it is suggested that self-rated health itself can be the independent predictor of mortality.
本研究旨在探讨即使排除先前研究报道的与死亡率相关的各种因素的影响后,自我评定健康状况是否仍是特定病因死亡率的独立预测因素。本研究纳入了1987年日本福冈县Y市随机选取的4259名居民(1827名男性和2432名女性),年龄在30至79岁之间。1987年通过自我管理问卷对这些受试者进行了关于自我评定健康状况以及生活习惯的调查,并对其生命状况和潜在死因进行了随访。在排除失访或未回答自我评定健康问题的个体后,对4046名个体进行分析,通过Cox比例风险模型观察自我评定健康状况与特定病因死亡率之间的关系,并对性别、年龄、吸烟、体重指数、医疗保健使用情况和日常生活活动能力进行了控制。结果显示,不健康组中所有病因、癌症、循环系统疾病和其他病因的相对风险分别为2.95(95%置信区间:1.93 - 4.50)、2.96(1.53 - 5.73)、2.32(0.86 - 6.26)和4.09(2.12 - 7.89)。在亚组分析中(1987年无疾病的受试者或随访后前3年内排除死亡病例的受试者),为避免选择偏倚,自我评定健康状况与死亡率之间的关联与先前分析结果基本相似,即使这种关联有所减弱。即使排除1987年患有疾病的受试者和随访后前3年内死亡的受试者,自我评定健康状况仍可能与所有病因的死亡率相关(风险比 = 1.89,95%置信区间;0.91 - 3.94)。从结果表明,自我评定健康状况本身可能是死亡率的独立预测因素。