泵灌注犬肾（原位）中的肾血流自动调节和肾静脉前列腺素
Renal blood flow autoregulation and renal venous prostaglandins in the pump-perfused canine kidney (in situ).
作者信息
Dighe K K, Hall J C, Smith G W, Ungar A
出版信息
Br J Pharmacol. 1977 Apr;59(4):571-5. doi: 10.1111/j.1476-5381.1977.tb07723.x.
Abstract
- Renal autoregulation of blood flow was re-examined in the pump-perfused canine kidney and concentrations of prostaglandins E and F in the renal venous plasma were measured by radioimmunoassay. 2. At low perfusion pressures, below the range of autoregulation, prostaglandin E and F concentrations rose and calculated prostaglandin E secretion rate fell. 3. Meclofenamate (10 mg/kg i.v.) reduced renal blood flow and prostaglandin E and F secretion rates, but did not abolish autoregulation. 4. Renal prostaglandins do not appear to mediate autoregulation in the kidney but may affect the level at which flow is controlled.
摘要
- 利用泵灌注犬肾重新研究了肾血流的自身调节，并通过放射免疫分析法测定了肾静脉血浆中前列腺素E和F的浓度。2. 在低于自身调节范围的低灌注压力下，前列腺素E和F的浓度升高，计算得出的前列腺素E分泌率下降。3. 甲氯芬那酸（静脉注射10mg/kg）降低了肾血流量以及前列腺素E和F的分泌率，但并未消除自身调节。4. 肾前列腺素似乎并不介导肾脏的自身调节，但可能会影响血流控制的水平。
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本文引用的文献
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Tissue pressure as a causal factor in the autoregulation of blood flow in the isolated perfused kidney.组织压力作为离体灌注肾脏血流自动调节的一个因果因素。
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Role of red blood corpuscles in regulation of renal blood flow and glomerular filtration rate.红细胞在调节肾血流量和肾小球滤过率中的作用。
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Prostaglandin-like substances appearing in canine renal venous blood during renal ischemia. Their patial characterization by pharmacologic and chromatographic procedures.肾缺血期间犬肾静脉血中出现的类前列腺素物质。通过药理学和色谱法对其进行部分特性鉴定。
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Increased juxtamedullary blood flow on stimulation of intrarenal prostaglandin biosynthesis.刺激肾内前列腺素生物合成时近髓血流量增加。
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Dependency of renal blood flow on prostaglandin synthesis in the dog.犬肾血流量对前列腺素合成的依赖性。
Circ Res. 1973 Jun;32(6):712-7. doi: 10.1161/01.res.32.6.712.
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Dose response relation of the renal effects of PGA1, PGE2, and PGF-2alpha--in dogs.前列腺素A1、前列腺素E2和前列腺素F-2α对犬肾脏作用的剂量反应关系
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Contribution of intrarenal generation of prostaglandin to autoregulation of renal blood flow in the dog.肾内前列腺素生成对犬肾血流自身调节的作用
Circ Res. 1973 Oct;33(4):428-36. doi: 10.1161/01.res.33.4.428.
9
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J Pharmacol Exp Ther. 1973 Mar;184(3):678-87.
10
Release of a prostaglandin-like substance into renal venous blood in response to angiotensin II.响应血管紧张素II，一种类前列腺素物质释放到肾静脉血中。
Circ Res. 1970 Jul;27(1 Suppl 1):121-30.
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