Smith G W, Somova L I
Br J Pharmacol. 1976 Oct;58(2):253-9. doi: 10.1111/j.1476-5381.1976.tb10403.x.
Renal hypertension was produced in rats and the changes in renal function, renal venous prostaglandin E2 and F2alpha concentrations and secretion rates were studied at various times. Renal plasma flow transiently fell in the ischaemic kidney 2 weeks after clamping, whilst that of the other kidney did not change. Glomerular filtration rate remained constant in both kidneys throughout the entire study. Prostaglandins E2 and F2alpha concentrations rose in the venous plasma from the ischaemic kidney, but did not change in the other kidney and appeared to be inversely related to renal plasma flow. Calculated secretion rate of both prostaglandins fell in the ischaemic kidney and did not change in the other kidney. Clamping the second kidney, two weeks after the first, caused a further elevation in blood pressure, a fall in renal plasma flow and a fall in prostaglandin secretion rate in both kidneys. The implications of these prostaglandin changes are discussed.
在大鼠中诱发肾性高血压，并在不同时间研究肾功能、肾静脉前列腺素E2和F2α浓度及分泌率的变化。夹闭后2周，缺血肾脏的肾血浆流量短暂下降，而另一肾脏的肾血浆流量未改变。在整个研究过程中，两个肾脏的肾小球滤过率均保持恒定。缺血肾脏静脉血浆中前列腺素E2和F2α浓度升高，而另一肾脏则未改变，且似乎与肾血浆流量呈负相关。两个肾脏中前列腺素的计算分泌率在缺血肾脏中下降，而在另一肾脏中未改变。在第一次夹闭两周后夹闭另一肾脏，导致血压进一步升高、肾血浆流量下降以及两个肾脏中前列腺素分泌率下降。讨论了这些前列腺素变化的意义。
