核黄素可降低铬酸盐对幼年和成年大鼠的肾毒性作用。

Riboflavin can decrease the nephrotoxic effect of chromate in young and adult rats.

作者信息

Appenroth D, Schulz O, Winnefeld K

机构信息

Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, Germany.

出版信息

Toxicol Lett. 1996 Sep;87(1):47-52. doi: 10.1016/0378-4274(96)03698-3.

DOI:10.1016/0378-4274(96)03698-3

PMID:8701444

Abstract

The influence of 5 mg vitamin B2/100 g b.wt. (B2, riboflavin) on the nephrotoxic effect of 1 or 2 mg Na2Cr2O7/100 g b.wt. (Cr) was investigated in 55- and 10-day-old rats, respectively. Nephrotoxic effect was evaluated by the determination of urinary volume and protein excretion as well as the concentration of blood urea nitrogen (BUN). The concomitant administration of Cr and B2 only in 55-day-old rats increased the nephrotoxicity shown by enhanced proteinuria and BUN. B2, administered 3 h after Cr, was able to diminish Cr nephrotoxicity significantly in 55- and 10-day-old rats. The effect of B2 on Cr nephrotoxicity could be interpreted not by the stimulatory effect of B2 on GSSG reductase, which was abolished by Cr; but by its antioxidant effect.

摘要

分别在55日龄和10日龄大鼠中研究了5毫克维生素B2/100克体重（B2，核黄素）对1或2毫克重铬酸钠/100克体重（Cr）肾毒性作用的影响。通过测定尿量、蛋白质排泄以及血尿素氮（BUN）浓度来评估肾毒性作用。仅在55日龄大鼠中同时给予Cr和B2会增加蛋白尿和BUN所显示的肾毒性。在Cr给药3小时后给予B2，能够显著降低55日龄和10日龄大鼠的Cr肾毒性。B2对Cr肾毒性的作用不能通过B2对谷胱甘肽二硫化物还原酶的刺激作用来解释，这种刺激作用会被Cr消除；而是通过其抗氧化作用来解释。