Kormilitsyna M I, Meshcheriakova I S
Zh Mikrobiol Epidemiol Immunobiol. 1996 Mar-Apr(2):3-6.
The natural isolate of F. tularensis subsp. holarctica 268 was detected and studied. The isolate possessed the properties of the vaccine strain: residual virulence for white mice, avirulence for guinea pigs and high immunogenicity for experimental animals. A significant decrease in its virulence for animals, highly sensitive to tularemia, was noted. In contrast to most virulent strains circulating in natural foci, F. tularensis strain 268 was characterized by the absence of growth at a cultivation temperature of 42 degrees C and had stable biological properties after 10-fold passage through white mice.
检测并研究了土拉弗朗西斯菌全北区亚种268的自然分离株。该分离株具有疫苗株的特性：对小白鼠有残余毒力，对豚鼠无毒性，对实验动物有高免疫原性。注意到其对土拉菌病高度敏感的动物的毒力显著降低。与自然疫源地中传播的大多数强毒株不同，土拉弗朗西斯菌268株的特点是在42摄氏度培养温度下不生长，并且在通过小白鼠传代10次后具有稳定的生物学特性。
