Lykova E A, Bondarenko V M, Izachik Iu A, Izachik N A, Grigor'ev A V, Murashov A O, Abramov N A
Zh Mikrobiol Epidemiol Immunobiol. 1996 Mar-Apr(2):88-91.
The state of microbiocenosis was studied and the level of immunoglobulins was determined in the gastric juice and feces of children with chronic diseases of the digestive system. In 20% of patients an increase in the contamination of the gastric biotope with opportunistic microflora was established. The isolation rate of Helicobacter pylori was 56%. The detection of H. pylori was found to be accompanied by the aggravation of the form and course of gastritis. In cases of Helicobacter-associated pathology the deficiency of Lactobacillus sp. in the stomach was established, which was accompanied by their deficiency and absence in feces. The study also revealed a decrease in the population level of Bifidobacterium sp. with a simultaneous increase in the population of opportunistic enterobacteria and changes in the state of local immunity: the decreased level of SIgA in most samples and the decreased level of IgG in the presence of H. pylori. The correction of microecological and immune disturbances with probiotic preparations, containing bifidobacteria (bifidumbacterin-forte) and lactobacilli, yielded good results.
对患有消化系统慢性疾病儿童的微生物群落状态进行了研究，并测定了其胃液和粪便中的免疫球蛋白水平。在20%的患者中，发现胃生物群落被机会性微生物污染增加。幽门螺杆菌的分离率为56%。发现幽门螺杆菌的检测伴随着胃炎形式和病程的加重。在幽门螺杆菌相关病理情况下，发现胃中乳酸杆菌属缺乏，同时粪便中也缺乏或不存在乳酸杆菌。研究还发现双歧杆菌属的种群水平下降，同时机会性肠杆菌种群增加，局部免疫状态发生变化：大多数样本中分泌型免疫球蛋白A水平降低，在存在幽门螺杆菌的情况下免疫球蛋白G水平降低。用含有双歧杆菌（强力双歧杆菌素）和乳酸杆菌的益生菌制剂纠正微生态和免疫紊乱取得了良好效果。
