Lykova E A, Vorob'ev A A, Bokovoĭ A G, Pobedinskaia I N, Gevondian V S, Gevondian N M, Mitrokhin S D, Minaev V I, Dzis N B, Makkaveeva L F, Kovalev I V, Murashova A O, Bondarenko V M
Central Clinical Hospital, Medical Centre of Managing Department of the President of the Russian Federation, Moscow.
Antibiot Khimioter. 2000;45(10):22-7.
One hundred and twenty-nine children with acute viral and bacterial infection of the respiratory tract were examined and disturbance of the large intestine microflora was detected. It was characterized by significant reduction of lactobacilli, moderate growth of opportunistic bacteria and higher contents of Candida. Changes in T- and especially B-cellular immunity were observed in 35 per cent of the patients. In patients with decreased avidity of the immunoglobulins G in the peripheral blood the changes were observed in 82-100 per cent of the cases. In the majority of the patients the capacity for interferon genesis was suppressed. A shorten course (5 days) of the bifidumbacterin forte therapy in a dose of not less than 10(9) CFU/ml. normalized the intestinal microflora, improved the indices of the B- and T-cellular immunity (including the subpopulation of the T-helper cells but not the T-suppressor cells), stimulated NK and improved the ability to induce alfa- and gamma-interferons of the peripheral blood leukocytes. The experience with using high doses of bifidumbacterin forte was evident of its good tolerance and possible value in increasing the patient resistance to infection.
对129例急性呼吸道病毒和细菌感染患儿进行了检查，发现其大肠菌群紊乱。其特征为乳酸杆菌显著减少、机会性细菌适度生长以及念珠菌含量较高。35%的患者观察到T细胞尤其是B细胞免疫发生变化。外周血中免疫球蛋白G亲和力降低的患者，82% - 100%的病例出现了变化。大多数患者的干扰素生成能力受到抑制。采用不低于10(9) CFU/ml剂量的强力双歧杆菌素进行为期5天的短疗程治疗，可使肠道菌群正常化，改善B细胞和T细胞免疫指标（包括辅助性T细胞亚群，但不包括抑制性T细胞），刺激自然杀伤细胞并提高外周血白细胞诱导α和γ干扰素的能力。使用高剂量强力双歧杆菌素的经验表明其耐受性良好，且在增强患者抗感染能力方面可能具有价值。
