Rosen P P, Menendez-Botet C J, Urban J A, Fracchia A, Schwartz M K
Cancer. 1977 May;39(5):2194-200. doi: 10.1002/1097-0142(197705)39:5<2194::aid-cncr2820390537>3.0.co;2-y.
We have studied 29 patients from whom two or more spatially and temporally separate samples of breast carcinoma were obtained for ERP analysis. Differences in ERP were obtained in 24% of all cases studied. The greatest degree of variation was found when comparing a primary tumor with a subsequent metastasis (38%). Among eight patients with ERP negative (-) primary tumors, six had ERP (-) and two ERP positive (+) metastases. Among 11 patients with ERP (+) primaries eight had ERP (+) and three ERP (-) metastases. Variations were found in 20% of multiple nonsimultaneous metastases from individual patients. The difference in average interval between cases that did not show variation (9.6 months) and those that did vary (19.3 months) suggests that variation may be more likely to occur with later metastases. However, there was considerable overlap in the range of intervals. These findings underscore the need to biopsy readily accessible recurrences rather than to rely on the results of prior specimens. There was no apparent consistent relationship of these variations to age, site of specimen, interval between specimens or the histologic features of the tissues submitted for analysis. Two patients with an ERP (+) primary tumor had ERP (-) metastases after interval therapy. Similar variations were observed in patients who did not have interval therapy. The data do not perimit any definite conclusions as to the effect of chemotherapy or radiation on the ERP properties of mammary carcinoma.
我们研究了29例患者，从他们身上获取了两个或更多在空间和时间上相互分离的乳腺癌样本用于ERP分析。在所有研究病例中，24%出现了ERP差异。在比较原发性肿瘤与后续转移瘤时，发现差异程度最大（38%）。在8例ERP阴性（-）原发性肿瘤患者中，6例转移瘤ERP（-），2例转移瘤ERP阳性（+）。在11例ERP（+）原发性肿瘤患者中，8例转移瘤ERP（+），3例转移瘤ERP（-）。在个别患者的多个非同时发生的转移瘤中，20%出现了差异。未显示差异的病例（9.6个月）与出现差异的病例（19.3个月）的平均间隔差异表明，差异可能更易发生在较晚的转移瘤中。然而，间隔范围有相当大的重叠。这些发现强调了对易于获取的复发灶进行活检的必要性，而不是依赖先前标本的结果。这些差异与年龄、标本部位、标本间隔或送检分析组织的组织学特征之间没有明显的一致关系。2例ERP（+）原发性肿瘤患者在间隔治疗后出现ERP（-）转移瘤。在未进行间隔治疗的患者中也观察到了类似的差异。关于化疗或放疗对乳腺癌ERP特性的影响，这些数据无法得出任何明确结论。
