Holdaway I M, Mason B H, Bennett R C, Alexander A I, Hahnel R, Kiang D T
Department of Endocrinology, University of Auckland, School of Medicine, New Zealand.
Cancer. 1988 Jul 1;62(1):109-13. doi: 10.1002/1097-0142(19880701)62:1<109::aid-cncr2820620120>3.0.co;2-t.
Estrogen receptor status, tumor histology, and the interval between the development of tumors were assessed in 99 patients with bilateral breast cancer. Tumors were first grouped into those simultaneously detected in both breasts or within 12 months of each other (synchronous bilateral breast cancer, of which there were 64) and second, those detected within more than 12 months of each other (asynchronous bilateral breast cancer, of which there were 35). Nineteen percent of all tumors were lobular carcinomas. Overall, the rate of receptor discordance between the two tumors was not significantly different from that previously reported between biopsies of primary tumor and metastases in patients with unilateral breast cancer. Synchronous receptor-positive tumors occurred significantly more frequently than expected, suggesting that the development of the two tumors was influenced by a common mechanism. In patients with asynchronous bilateral breast cancer there was a significantly longer interval between tumors if both were receptor-positive compared with concordant receptor-negative tumors and tumors with discordant receptor status. There was a significant discordance in the receptor status of asynchronous tumors when the histology also differed, indicating that the tumors in this group were likely to be separate primary tumors.
对99例双侧乳腺癌患者的雌激素受体状态、肿瘤组织学类型以及肿瘤发生间隔进行了评估。肿瘤首先被分为在双侧乳房同时检测到或彼此间隔在12个月内的（同步双侧乳腺癌，共64例），其次是彼此间隔超过12个月检测到的（非同步双侧乳腺癌，共35例）。所有肿瘤中有19%为小叶癌。总体而言，两个肿瘤之间受体不一致的发生率与先前报道的单侧乳腺癌患者原发性肿瘤活检与转移灶之间的情况相比，无显著差异。同步受体阳性肿瘤的发生频率显著高于预期，提示两个肿瘤的发生受共同机制影响。在非同步双侧乳腺癌患者中，如果两个肿瘤均为受体阳性，则其间隔时间显著长于受体阴性一致的肿瘤以及受体状态不一致的肿瘤。当组织学类型也不同时，非同步肿瘤的受体状态存在显著不一致，表明该组肿瘤可能是独立的原发性肿瘤。
