Yao W X, Xia G J, Zheng Q, Liu D, Jiang M X
Department of Pharmacology, Tongji Medical University, Wuhan.
Yao Xue Xue Bao. 1995;30(9):651-4.
The present study indicates that iv tetrandrine may transiently decrease blood pressure, while other hemodynamic parameters such as LVP, +/- dp/dtmax, LVEDP, HR and CO may not be significantly altered. During coronary occlusion three of five dogs developed ventricular fibrillation (VF) and died in the control group, i.e. incidences of VF and mortality were 60%. While tetrandrine (Tet) appeared to reduce the severity of ischemic injury. It may alleviate arrhythmia and prevent VF and death in four of the five dogs. Tet also attenuated Ca2+ accumulation in myocardial cell, reduced melondialdehyde (MDA) production in ischemic myocardial and decreased CPK release in comparison with the control. It appears that Tet may have significant protective effects against ischemia induced cardiac damage in anesthetized dogs.
本研究表明，静脉注射粉防己碱可能会使血压短暂下降，而其他血流动力学参数，如左心室压力（LVP）、±dp/dtmax、左心室舒张末期压力（LVEDP）、心率（HR）和心输出量（CO）可能不会有显著改变。在冠状动脉闭塞期间，对照组五只狗中有三只发生心室颤动（VF）并死亡，即VF发生率和死亡率为60%。而粉防己碱（Tet）似乎减轻了缺血损伤的严重程度。它可能减轻心律失常，并预防五只狗中的四只发生VF和死亡。与对照组相比，Tet还减少了心肌细胞中Ca2+的蓄积，降低了缺血心肌中丙二醛（MDA）的生成，并减少了肌酸磷酸激酶（CPK）的释放。看来Tet可能对麻醉犬缺血性心脏损伤具有显著的保护作用。
